TIGER is an EU funded Horizon 2020 project related to highly innovative therapeutic mRNA-based cancer vaccines to target hard to treat cancers
TIGER promotes the current revolution in mRNA-based technologies that offer unparalleled opportunities for developing new therapeutics targeting cancers with high unmet clinical needs
European Union’s grant agreement
No 945011
Drug and Biomarkers
HPV+ Cancers
Patient information
The TIGER project
TIGER has advanced the use of proprietary lipid nanoparticles (LNP) for new mRNA-therapeutics with the potential to revolutionise care for cancer patients.
Successful clinical development of mRNA therapies should deliver innovative affordable new treatments that yield a significant improvement on the current therapeutic approach and standard of care for patients.
The project also advances exciting and innovative biomedical diagnostics to provide new tools to support later stage clinical studies, future oncology therapy development and patient stratification. mRNA cancer vaccine platforms can be combined with different antigens to target different cancers. This project will promote further applications of the technology in a wide range of cancers.
Our project video is also available to watch in French, German, Dutch and Flemish.
Our objectives
Identify novel imaging biomarkers using radiomics to evaluate early tumour response and investigate tumour responses to EI-201 treatment.
Develop and validate a novel assay to measure circulating tumour DNA (ctDNA) derived from HPV16+ tumours which could be applied as a biomarker for measuring the effect of cancer therapies on HPV+ tumour burden.
Clinical programme
Clinical programme are used by drug developers to advance the candidate products through critical early safety and efficacy studies. Later stage studies confirm efficacy and dose against target cancers. Successful clinical trial data provides the evidence for first regulatory approval for the treatmnet to reach the clinic. Clinical trials also often improve standard of care.
Latest news
January is cervical cancer awareness month
The TIGER project is proud to support Cervical Cancer awareness month this January.
